Physicochemical Analysis and Molecular Modeling of the Fosinoprilβ-Cyclodextrin Inclusion Complex
نویسندگان
چکیده
منابع مشابه
Molecular modeling of β-cyclodextrin inclusion complexes with pharmaceutical compounds
Ten molecularly diverse compounds, selected on the basis of the standard free energy of complexation with β-cyclodextrin, have been used as training set of molecular docking experiments. After the conformational search of each compound the Molecular Interaction Evaluation (MOLINE) program has been adopted to generate the inclusion geometries. The recognition process has been thermodynamically e...
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The inclusion complexes of poorly water-soluble cephalosporin, cefuroxime axetil (CFA), were prepared with β-cyclodextrin (βCD) with or without addition of l-arginine (ARG) to improve its physicochemical properties. We also investigated the effect of ARG on complexation efficiency (CE) of βCD towards CFA in an aqueous medium through phase solubility behaviour according to Higuchi and Connors. A...
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Purpose: To investigate the suitability of glucosyl-β-cyclodextrin (G-β-CD) to form inclusion complex with catechin, and characterize the physicochemical properties of the inclusion complex of catechin and G-β-CD. Methods: Catechin and G-β-CD was mixed in water at the same molar ratio, stirred at 20 °C for 48 h and lyophilized to obtain the complex. Its physicochemical properties were investiga...
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This paper presents physicochemical characterization, dissolution behavior and release kinetics of curcumin and its molecular inclusion complexes with β-cyclodextrin. Solid inclusion complexes of curcumin with β-cyclodextrin in 1:2 molar ratios were prepared by grinding, kneading and freeze drying methods. Complexes were characterized by differential scanning calorimetry, infra red spectroscopy...
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ژورنال
عنوان ژورنال: Journal of Spectroscopy
سال: 2014
ISSN: 2314-4920,2314-4939
DOI: 10.1155/2014/748468